People with histamine intolerance are deficient in the enzyme diamine oxidase (DAO), which is responsible for breaking down histamine. When the amount of histamine in the body is too high, it can lead to various symptoms such as are headache, rash, indigestion, asthma, low blood pressure and heart arrhythmia.

Histamine is an organic compound that plays a key role in many physiological processes in the body. It belongs to the biogenic amines and is produced by cells of the immune system, especially mast cells cells and basophils. Histamine is released during allergic reactions and immune responses to infection.

Histamine intolerance arises for several reasons and can be caused by various factors. Here are the main causes of histamine intolerance:

• DAO (diamine oxidase) deficiency: DAO is the main enzyme responsible for breaking down histamine in the digestive tract. Genetic factors or intestinal disease can lead to insufficient production of DAO.
• Excessive histamine intake in food: Eating large amounts of histamine-rich foods can overwhelm the body's ability to break down histamine.
• Intestinal imbalance: Disruption of the intestinal microflora can affect the production and function of DAO. Leaky gut syndrome can increase histamine absorption.
• Chronic inflammatory diseases: Certain diseases, such as allergies or autoimmune disorders, can increase the release of histamine in the body.
• Drugs: Some drugs can block DAO or increase the release of histamine.

• Hormonal changes: Changes in hormone levels, such as during the menstrual cycle or menopause, can affect histamine metabolism.
• Stress: Chronic stress can affect gut and immune system function, which can contribute to histamine intolerance.
• Vitamin and mineral deficiency: A deficiency of vitamin B6, vitamin C, copper or zinc can affect the metabolism of histamine.
• Genetic predisposition: Certain genetic variations can increase susceptibility to histamine intolerance.
• Other diseases: Certain liver or kidney diseases can affect the body's ability to break down histamine.

It is important to note that histamine intolerance is often a complex condition that can be caused by a combination of these factors.

Diagnosing histamine intolerance can be tricky because symptoms often overlap with other health problems. Here are the main methods used to diagnose histamine intolerance:

• History and clinical signs:
• The doctor will evaluate in detail the patient's symptoms and their connection with food. Typical symptoms include headaches, skin rashes, indigestion, low blood pressure, or breathing problems after eating foods rich in histamine.
• Elimination diet: The patient follows a strict low-histamine diet for 2-4 weeks. Subsequently, it is monitored whether the symptoms are alleviated.
• Provocation test: After the elimination diet, foods rich in histamine are gradually introduced. It is being watched to see if symptoms return.
• Blood tests: Measurement of histamine levels in the blood. Determination of DAO (diamine oxidase) enzyme activity. However, these tests are not always reliable and can give false negative results.

• Skin tests: Some clinics perform histamine skin tests, but their reliability is debatable.
• Genetic tests: Can reveal genetic predispositions to histamine intolerance, especially mutations affecting DAO function.
• Intestinal mucosal biopsy: In some cases, this may be done to measure DAO activity in the intestines.
• Ruling out other diseases: It is important to rule out other conditions that may have similar symptoms, such as allergies or intolerances to other foods.
• Food and symptom diary: The patient keeps a detailed record of foods eaten and symptoms experienced, which can help identify connections.
• Consultation with an allergist or gastroenterologist: Specialists can perform other specific examinations and provide a professional assessment.

It is important to note that there is no single reliable test for diagnosing histamine intolerance. The diagnosis is often made based on a combination of clinical signs, the results of an elimination diet, and the exclusion of other possible causes.

Histamine occurs naturally in many foods, especially those that have been fermented, such as cheeses, cured meats, and alcoholic beverages. Some people may have trouble breaking down histamine, which leads to histamine intolerance and various symptoms such as headaches, indigestion and rashes.
In the case of histamine intolerance, it is important to monitor and limit the intake of foods that contain high amounts of histamine or may trigger the release of histamine in the body. Here are some general recommendations for a histamine intolerance diet:

Avoid foods high in histamine:

• Fermented products (cheeses, sauerkraut, soy sauce).
• Alcoholic beverages, especially red wine and beer.
• Smoked and preserved meat (ham, salami, sausages).
• Fish and seafood, especially if not fresh.
• Ripe fruits (bananas, avocados, strawberries).
• Some vegetables (tomatoes, spinach, eggplant).

Limit foods that can release histamine:

• Citrus fruits (oranges, lemons, grapefruits).
• Chocolate and cocoa products.
• Nuts, especially cashews and walnuts.
• Some spices and herbs (curry, chili).

Keep food fresh:

• Histamine increases in aging and poorly stored foods. Try to eat the freshest foods possible and avoid leftovers.

Diary keeping:

• Keeping a food diary is important for tracking which foods trigger symptoms and how your body reacts to them.

Individual tolerance testing:

• It is always important to monitor how the body reacts to individual ingredients. Start with small amounts and watch for possible symptoms.

With histamine intolerance, it is important to choose foods and ingredients that have a low histamine content and do not promote its release. Below are listed which of the mentioned ingredients are suitable and which should be omitted or limited.
Ingredients suitable for histamine intolerance:

• 1. Pea protein: Generally considered safe, but may depend on individual sensitivity.

2. Rice Extract: Generally safe. 3. Broccoli: Safe, low in histamine. 4. Spirulina: May be problematic for some people with histamine intolerance. Try with caution. 5. Chia seeds: Safe. 6. Mango: Usually safe in small amounts. 7. Blueberries: Safe. 8. Fish collagen, beef collagen: Can be problematic, depends on individual sensitivity. 9. Hemp protein: Safe, does not have a high histamine content and does not promote its release.

Histamine intolerance

• 1. Strawberries: They can release histamine, so it is better to avoid or limit them.

2. Banana: Sometimes it can be problematic, depends on individual sensitivity. 3. Spinach: It is generally considered to be a food with a higher histamine content and can increase its levels in the body. It is recommended to avoid or consume very carefully, according to individual sensitivity. 4. Chlorella: can be problematic for some people and cause histamine reactions. It is recommended to try with caution. 5. Young barley: Like chlorella, young barley can be problematic for some people with histamine intolerance. It is recommended to try with caution.

CBD oil (cannabidiol) has become a popular dietary supplement due to its potential health benefits, including anti-inflammatory and anxiolytic effects. Some studies and user experiences suggest that CBD oil could have a beneficial effect on histamine
1. Anti-inflammatory effects:
Histamine intolerance is often related to chronic inflammation in the body. CBD has anti-inflammatory properties that could help alleviate some of the inflammatory responses associated with histamine intolerance.
2. Regulation of the immune system:
• CBD can modulate the immune response, which can be useful in reducing the overreaction of the immune system that occurs in histamine intolerance.
3. Reducing anxiety and stress:
• Stress and anxiety can worsen the symptoms of histamine intolerance. CBD is known for its anxiolytic effects, which can help reduce stress and improve overall well-being.
Dosage:
Start with a low dose of CBD oil and gradually increase it if needed. Recommended dosage may vary depending on individual needs and sensitivities.
Choosing a quality product:
Make sure you choose a quality CBD oil from a reputable manufacturer. The product should be tested by a third party for purity and cannabinoid content.

Based on the above information, people with histamine intolerance can consume the following TMF products:

• TMF Superlife chia&mango
• TMF Superlife blueberry&acai
• TMF Detox drink - to draw attention to possible problems due to the spinach content.
• TMF Protein Porridge coconut / vanilla
• TMF Protein Porridge apple / cinnamon
• And we definitely recommend TMF CBD ENERGY 10.0%
• TMF CBD STARTER 10.0%, TMF CBD SLEEP 10.0%
• TMF Hemp protein